Sempat Unggul 2 Gol, Fiorentina Tersisih dari Liga Europa

Olympique Lyon 7-1 AZ Alkmaar (Nabil Fekir 5', 27', 78', Gnaly Maxwell Cornet 17', Sergi Darder 34', Houssem Aouar 87', Mouctar Diakhaby 89' ; Levi Garcia 16') - Lyon lolos, agregat 11-2

Shakhtar Donetsk 0-2 Celta Vigo (Iago Aspas 90'-penalti, Gustavo Cabral 108') - Celta lolos, agregat 2-1 

Sparta Prague 1-1 FC Rostov (Vyacheslav Karavaev 83' ; Dmitry Poloz 13') - Rostov lolos, agregat 5-1

Tottenham Hotspur 2-2 Gent (Christian Eriksen 10', Victor Wanyama 61' ; Harry Kane 20'-bunuh diri, Jeremy Perbet 82') - Gent lolos, agregat 3-2