Saint-Etienne 0-1 Manchester United (Henrikh Mkhitaryan 17') - Manchester United lolos, agregat 4-0
Osmanlispor 0-3 Olympiacos (Karim Ansarifard 47', 86', Tarik Elyounoussi 70') - Olympiacos lolos, agregat 3-0
APOEL Nicosia 2-0 Athletic Bilbao (Pieros Sotiriou 46', Giannis Gianniotas 54'-penalti) - APOEL lolos, agregat 4-3
Ajax Amsterdam 1-0 Legia Warszawa (Nick Viergever 49') - Ajax lolos, agregat 1-0
Besiktas 2-1 Hapoel Beer Sheva (Vincent Aboubakar 17', Cenk Tosun 87' ; Anthony Nwakaeme 64') - Besiktas lolos, agregat 5-2
AS Roma 0-1 Villarreal (Rafael Santos Borre 16') - AS Roma lolos, agregat 4-1
Zenit St. Peterseburg 3-1 Anderlecht (Giuliano 24', 78', Artem Dzyuba 72') - Anderlecht lolos karena agresivitas gol tandang, agregat 3-3
FC Kobehavn 0-0 Ludogorets - Kobenhavn lolos, agregat 2-1
Fiorentina 2-4 Borussia Moenchengladbach (Nikola Kalinic 16', Borja Valero 29' ; Lars Stindl 44'-penalti, 47', 55', Andreas Christensen 60') - Gladbach lolos, agregat 4-3
Genk 1-0 Astra Giurgiu (Alejandro Pozuelo 67') - Genk lolos, agregat 3-2